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We've found that the extent of aggregation of Covaspheres coated with either Ng-CAM or N-CAM was strongly inhibited by
the intact 1D1 and 3F8 chondroitin sulfate proteoglycans of rat brain, and by the core glycoproteins resulting from chondroitinase remedy of the proteoglycans.
The early postnatal form (neurocan) was discovered to bind neurons more successfully than the
grownup proteoglycan, which repreesents the C-terminal half of the bigger neurocan core protein. Immunolcytochemical methods had been used to indicate that Ng-CAM (the neuron-glia cell adhesion molecule), N-CAM (the neural cell adhesion molecule), and the extracelluular matrix protein cytotactin are highly concentrated at nodes of
Ranvier of the grownup rooster and mouse. Among the many numerous CAMs expressed in the brain, the latest on the neurogenic observe
is Car (coxsackievirus and adenovirus receptor), a single-move transmembrane protein belonging to the Ig superfamily.3 Its features are best
described in epithelia the place homodimeric interactions in trans help regulate and maintain tight junction homeostasis.4,5 There are
a few membrane-bound and soluble Car isoforms created by various
splicing, however the predominant isoform within the brain iis the
∼46 kDa membrane sure protein.

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